• Mandana Khalili, Nicole J Kim, Janice Y Tsoh, WalshJudith M EJMEDivision of General Internal Medicine, University of California San Francisco, San Francisco, CA, USA., L Elizabeth Goldman, Ginny Gildengorin, Ching Wong, Mi T Tran, Edgar Yu, Michael Thanh Sharp, Vivian H LeTran, Vi-Van Nguyen, and Tung T Nguyen.
• Division of Gastroenterology and Hepatology, University of California San Francisco, San Francisco, CA, USA. Mandana.Khalili@ucsf.edu.
• J Gen Intern Med. 2022 Oct 1; 37 (13): 324232503242-3250.

BackgroundThere are few studies to date of interventions to increase viral hepatitis screening among Asian Americans, who have high rates of chronic hepatitis B (HBV) infection.ObjectiveTo develop, implement, and test the efficacy of a mobile application (Hepatitis App) delivered in four languages to increase HBV screening among Asian Americans.DesignCluster-randomized clinical trial.ParticipantsFour hundred fifty-two Asian American patients ≥ 18 years of age, who had no prior HBV testing, and received primary care within two healthcare systems in San Francisco, CA.InterventionsThe intervention group received the Hepatitis App, delivering interactive video education on viral hepatitis in English, Cantonese, Mandarin, or Vietnamese and a provider printout (Provider Alert) and Provider Panel Notification. The comparison group received a mobile application delivering nutrition and physical activity education and Provider Panel Notification.Main MeasuresPrimary outcomes were patient-provider discussion about HBV and documentation of a HBV screening test within 3 months post-intervention. Secondary outcome was documentation of an order for a HBV screening test.Key ResultsParticipants had a mean age of 57 years and were 64% female, 80% foreign-born, and 44% with limited English fluency. At post-visit, over 80% of intervention participants reported they liked using the Hepatitis App. At 3-month follow-up, the intervention group was more likely than the comparison group (all P < 0.001) to have discussed HBV with their provider (70% vs.16%), have a HBV test ordered (44% vs.10%), and receive a HBV test (38% vs.8%). In multivariable analyses, the intervention odds ratio for HBV test ordering was 7.6 (95% CI: 3.9, 14.8) and test receipt was 7.5 (95% CI: 3.6, 15.5).ConclusionsA multi-lingual educational intervention using a mobile application in primary care clinics was well received by Asian American patients, enhanced patient-provider communication about HBV, and increased HBV screening. Technology can improve healthcare quality among Asian Americans.Trial RegistrationClinicalTrials.gov NCT02139722 ( https://clinicaltrials.gov/ct2/show/NCT02139722 ).© 2021. Society of General Internal Medicine.

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