• Wenjun Luo, Yan Zhai, Mi Sun, Dong Guo, Fang Xie, Zhou Yu, and Zunhao Tang.
• Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
• Medicine (Baltimore). 2022 Jan 14; 101 (2): e28296e28296.

BackgroundCOVID-19 is an acute respiratory infectious disease, which makes people difficult to breathe; in addition, it is often accompanied by headache, olfaction, and taste disorders of the neurological manifestations. Acupuncture has been proved to have a therapeutic effect on various neurologic manifestations. This study is designed to evaluate the effectiveness and safety of acupuncture for the neurologic manifestations in COVID-19.MethodsRandomized controlled trials from December 2019 to July 2021 will be included without restrictions on language or publication date. PubMed, EMBASE, Cochrane Library, Web of Science, Chinese Biomedical Databases (CBM), China National Knowledge Infrastructure (CNKI), Wanfang database, and VIP database will be searched. Two researchers will independently select studies, extract data, and evaluate study quality. Cochrane risk of bias tool for randomized trials will be used to assess the risk of bias of included studies. Statistical analyses will be performed using the Review Manager V.5.3 and stata 14.0.Ethics And DisseminationThis study will not involve personal information. Ethical approval will not be required. We will publish the results in a peer-reviewed journal.Prospero Trial Registration NumberCRD42021265699.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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