Medicine
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The role of ambroxol hydrochloride combined with fiberoptic bronchoscopy in elderly patients with severe pneumonia remains unclear, we aimed to analyze this issue to provide evidences into the management of clinical pneumonia. ⋯ The high-dose ambroxol hydrochloride combined with fiberoptic bronchoscopy is beneficial to improve the patient's blood gas indicators, and reduce mortality in elderly patients with severe pneumonia.
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Review Case Reports
MR imaging features of Lhermitte-Duclos disease: Case reports and literature review.
Lhermitte-Duclos disease (LDD) is a rare tumor of the nervous system with a typical "tiger striped'" sign, but its features on functional magnetic resonance imaging (fMRI) are still inconclusive. ⋯ Magnetic resonance spectroscopy and susceptibility-weighted imaging combined with conventional MRI can be used to better diagnose LDDs. Perfusion-weighted imaging is not specific for distinguishing cerebellar tumors. The combined application of fMRI and conventional MRI can improve the accuracy of LDD diagnoses.
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As the main force in the development of healthcare, nurses have the longest contact time with patients in clinical practice, their perception of the hospital ethical climates affecting nurses' attitudes and related ethical issues. hospital ethical climates have become an essential environmental factor for nurses to make and implement ethical decisions. ⋯ There is a correlation between nurses' perceptions of hospital ethical climate and organizational citizenship behavior, nurses' perceptions of hospital ethical climate influencing nurses' organizational citizenship behavior in different ways. Managers should focus on the changes of nurses' perception of hospital ethical climates, to promote the nurse to make more beneficial behavior to the organization.
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We previously developed a computerized clinical decision support system based on national consensus guidelines and previous studies. This system was used to assess the risk of venous thromboembolism. In this study, we examined the risk factors for venous thromboembolism in patients who underwent lower limb orthopedic surgery using our risk scoring system, to investigate the association between the total risk score and the occurrence of venous thromboembolism. ⋯ Our risk scoring system may be used preoperatively to determine the need for venous thromboembolism prophylaxis. This study suggests that age (≥68 years) may be a risk factor for venous thromboembolism after lower limb orthopedic surgery. Additional studies are needed to validate these results.
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The present study aimed to investigate the comprehensive expression profiles of long non-coding RNA (lncRNA) in ankylosing spondylitis (AS). The peripheral blood samples were collected from 6 AS patients and 6 age- and gender-matched healthy controls (HCs), and separated for peripheral blood mononuclear cells, followed by RNA-sequencing. ⋯ Principal component analysis plots indicated that both lncRNA and mRNA expression profiles could distinguish AS patients from HCs; heatmap diagram exhibited a relatively good consistency and tendency of lncRNA and mRNA expression profiles in AS patients and HCs, respectively; volcano plots exhibited 114 upregulated and 45 downregulated DElncRNAs, 284 upregulated and 435 downregulated DEmRNAs in AS patients compared with HCs; Gene ontology enrichment analyses indicated that DElncRNAs (based on cis-target and trans-target genes) and DEmRNAs were enriched in molecular functions (including DNA binding, protein binding, etc) and biological process (including immune response, inflammatory response, etc); Kyoto Encyclopedia of Genes and Genomes enrichment analyses revealed that these DElncRNAs (based on cis-target and trans-target genes) and DEmRNAs were enriched in immune and inflammation-related signaling, such as B cell receptor signaling pathway, TNF signaling pathway, NF-kappa B signaling pathway, etc. Our study displays the comprehensive expression profiles and functions of lncRNAs involved in AS, which provides reference for further researches discovering candidate lncRNAs with value in assisting early AS diagnosis.