• Sotaro Ozaka, Takamoto Kodera, Shimpei Ariki, Takashi Kobayashi, and Kazunari Murakami.
• Department of Gastroenterology, Faculty of Medicine, Oita University, Oita, Japan.
• Medicine (Baltimore). 2022 Jan 14; 101 (2): e28471e28471.

RationaleIn response to the global coronavirus infectious disease 2019 (COVID-19) pandemic, several vaccines against severe acute respiratory syndrome coronavirus 2 have been developed. Although many infrequent side effects of COVID-19 mRNA vaccine have been reported, only a few cases of pancreatitis have been reported.Patient ConcernsA 71-year-old woman was presented to the hospital with upper abdominal pain and vomiting. She had no history of alcohol consumption, pancreatitis, or allergic reactions to vaccines. She had received the first dose of the Pfizer/BioNTech COVID-19 mRNA vaccine 2 days prior to her current presentation. Laboratory tests revealed elevated serum pancreatic enzymes. An abdominal computed tomography scan showed diffuse enlargement of the pancreas with fat stranding extending to below the kidneys bilaterally.DiagnosisThe patient was diagnosed with acute pancreatitis.InterventionsThe patient was treated with the administration of intravenous antimicrobials, proteolytic enzyme inhibitors, and proton pump inhibitors.OutcomesThe patient had an uneventful recovery with no complications.LessonsAcute pancreatitis can develop shortly after COVID-19 mRNA vaccination. Therefore, of great importance to differentiate acute pancreatitis when abdominal pain occurs after COVID-19 mRNA vaccination.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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