• Yong Tae Hong, Yunna Yang, and Hyunjun Lee.
• Department of Otolaryngology-HNS1, Research Institute for Clinical Medicine of Jeonbuk National University- Biomedical Research Institute of Jeonbuk National University Hospital, Chonbuk, Korea.
• Medicine (Baltimore). 2022 Jan 14; 101 (2): e28473e28473.

RationaleMyxoid liposarcoma (MLS) is an extremely rare tumor of the salivary gland and it arises from undifferentiated pluripotent mesenchymal cells. We report a rare case of a primary MLS in the parotid gland.Patient ConcernsThe patient was a 49-year-old female who presented with a hard fixed mass in the left parotid region.DiagnosisOn computed tomography and MR images, this tumor has a low attenuation center with a thick enhancing wall and ill-defined margins. The absence of high-signal-intensity foci on T1-weighted images makes a MLS indistinguishable from most other soft-tissue masses. Pathologically, the tumor was diagnosed as MLS.InterventionsThe patient received total parotidectomy with facial nerve preservation and selective neck dissection.OutcomesImmediate facial nerve function was House Brackmann Grade III and recovered within 3 months after the surgery. Follow-up period is 57 months and there was no recurrence until now.LessonsIn this report, we report a rare case of primary MLS mimicking a cystic lesion of the parotid gland.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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