• Medicine · Jan 2022

    Effectiveness and safety of auricular therapy for post-stroke depression: A protocol for systematic review and meta-analysis.

    • Mingzhi Tang, Sisi Feng, Yihao Zhou, Wenjing Zhang, Yu Wang, Dan Feng, Yong Qin, Yang Chen, Yanan Hu, and Haijing Liu.
    • Yunnan University of Traditional Chinese Medicine, Kunming, China.
    • Medicine (Baltimore). 2022 Jan 14; 101 (2): e28505e28505.

    BackgroundPost-stroke depression is a common and serious complication after stroke. Its main clinical manifestations are depression or instability, loss of interest, loss of appetite, sleep disorders, pessimism, and unworthiness, and even suicidal tendencies. Auricular therapy (AT), as part of traditional Chinese acupuncture, has achieved good results in the treatment of depression, but different clinical studies have shown mixed results. Therefore, the aim of this systematic review is to assess the effectiveness and safety of AT for post-stroke depression.MethodsTwo reviewers will electronically search the following databases: the Cochrane Central Register of Controlled Trials; Medline (via PubMed); Excerpt Medica Database; China National Knowledge Infrastructure; Chinese Biomedical Literature Database; Chinese Scientific Journal Database; and Wan-Fang Database from the inception to January 1, 2022. Study selection, data extraction, and assessment of study quality will be performed independently by 2 reviewers. If it is appropriate for a meta-analysis, Review Manager Version 5.3 statistical software will be used; otherwise, a descriptive analysis will be conducted. Data will be synthesized by either the fixed-effects or random-effects model according to a heterogeneity test. The results will be presented as risk ratio with 95% confidence intervals for dichotomous data and weight mean difference or standard mean difference 95% confidence intervals for continuous data.ResultThis study will provide a comprehensive review of the available evidence for the treatment of AT with post-stroke depression.ConclusionsThe conclusions of our study will provide an evidence to judge whether AT is an effective and safe intervention for patients with post-stroke depression.Trial Registration NumberPROSPERO CRD42021289870.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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