• Xin Long, Yan Chen, Wei-Xun Chen, Yu Wu, Jia Song, Jin Chen, and Lei Zhang.
• Hepatic Surgery Center, Institute of Hepato-Pancreato-Biliary Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
• Medicine (Baltimore). 2022 Jan 14; 101 (2): e28549.

IntroductionPrimary spindle cell sarcoma of the gallbladder is a rare condition.Patient ConcernsA 67-year-old woman was admitted to a local hospital with a chief complaint of abdominal pain in the right upper quadrant for the past 2 months.Diagnosis And InterventionSurgical resection was performed following the diagnosis of primary gallbladder sarcoma with local hepatic metastasis. Histological examination confirmed a diagnosis of primary spindle cell sarcoma and hepatic metastasis with simultaneous cholecystolithiasis.OutcomesAdjuvant chemoradiation therapy was not performed because the patient refused treatment. Three months after the surgery, a relapsed lesion was diagnosed. The patient underwent transcatheter arterial chemoembolization.ConclusionsThe disease should be differentially diagnosed from gallbladder carcinoma or carcinosarcoma with hepatic metastasis. An aggressive surgical approach should be based on a balance between the risk of surgery and the outcome.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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