• Peng Yin, Sheng Han, Qingfeng Hu, and Shijun Tong.
• Department of Urology, Jiaozhou People's Hospital, Jiaozhou, Shangdong, China.
• Medicine (Baltimore). 2022 Jan 7; 101 (1): e28513.

Objectives: To investigate the association between statin use and biochemical recurrence (BCR) in patients undergoing radical prostatectomy (RP) or radiotherapy (RT) as a curative treatment, a systematic review and meta-analysis was performed.Methods: We conducted a literature search of online databases for studies assessing BCR associated with statin use in patients with prostate cancer undergoing RP or RT. We performed a pooled analysis of BCR-free survival with subgroup analysis of treatment, cancer risk, and medication.Results: We identified 27 studies and found that statin use was associated with a potential tendency to improve BCR-free survival in patients undergoing curative treatment (P = .05). In addition, we revealed that statin use after curative treatment did not improve BCR-free survival (P = .33), whereas statin use could improve BCR-free survival in high-risk patients (P < .01).Conclusions: Statin use is associated with a potential tendency to improve BCR-free survival in prostate cancer and could reduce BCR in high-risk patients.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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