• Amal M Obeid, Faiza A Qari, Soad K Aljaouni, Sawsan Rohaiem, Ahmed A Elsayed, Maha M Alsayyad, and Ezzuddin A Okmi.
• From the Department of YAJ chair for Prophetic medical applications (Obeid, Alsayyad), Cupping Therapy Clinics; from the Department of Hematology (Aljaouni), Yousef Abdulatif Jameel Scientific Chair of Prophetic Medicine Application, from the Department of Medicine (Qari); from the Department of Physiology (Rohaiem); From the Faculty of Medicine (Alsayyad), King Abdulaziz University, Jeddah, from the Department of Communicable Diseases Prevention and Control (Okmi), Public Health Authority, Riyadh, Kingdom of Saudi Arabia, and from the Department of Radiology (Elsayed), The Royal Wolverhampton Trust, New Cross Hospital, London, United Kingdom.
• Saudi Med J. 2022 Jan 1; 43 (1): 45-52.

ObjectivesTo investigate the possible effects of wet-cupping therapy (hijama) on autoimmune activity and thyroid hormonal profiles of Hashimoto's disease (HD) patients.MethodsA prospective pilot controlled trial was carried out among adult females following HD at the Endocrinology Clinic of King Abdulaziz University Hospital, Jeddah, Saudi Arabia, from February 2014 until March 2017. A total of 13 patients (intervention group) underwent 3 hijama sessions at 3-week interval with a 6-month follow-up. Blood tests were carried out for both pre- and post-hijama, including: thyroid peroxidase antibody (TPO), thyroglobulin antibody (TG), thyroid stimulating hormone (TSH), thyroxine-4 (T4), and prolactin. Control group included 13 randomly selected HD patients following usual care with 2 consecutive measurements of TPO and TG at 2-3 months interval.ResultsChanges in anti-TPO and anti-TG showed a decrease in hijama group versus an increase in control group, and intervention group comparison was statistically significant. On a fixed thyroxine supplement for each patient, significant decrease in levels of anti-TPO, anti-TG, TSH, prolactin, and erythrocyte sedi-mentation rate (ESR) occurred.ConclusionThese findings are presumptive to the efficacy of hijama on the pathogenesis of HD in modulating the immune inflammatory process demonstrated by the reduction in ESR, TPO, and TSH levels on a fixed thyroxin supplementation dose, along with patient-reported clinical improvement and positive changes in ultrasound including regaining of gland physiological size, echogenicity, and vascularity.Copyright: © Saudi Medical Journal.

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