• Humaira Fayyaz Khan, Shazadi Ambreen, Hammad Raziq, and Azmat Hayat.
• Dr. Humaira Fayyaz Khan, MBBS, FCPS Physiology, MHPE, Department of Physiology, Riphah International University, Islamabad, Pakistan.
• Pak J Med Sci. 2022 Jan 1; 38 (1): 185-189.

ObjectivesTo compare the levels of cortisol in patients of vasovagal syncope (VVS) and postural tachycardia syndrome (POTS).MethodsA cross-sectional analytical study was conducted at Islamic International Medical College, Rawalpindi and Electrophysiology Department at (AFIC). This study included 80 subjects, comprising of 35 patients in each group of vasovagal syncope and postural tachycardia syndrome and 10 healthy subjects. Patients with complaint of syncope was evaluated for vasovagal syncope and postural tachycardia syndrome using Head Up Tilt Test (HUTT. Blood samples of all the participants were taken and serum cortisol was analyzed using ELISA method. Results were analyzed on SPSS Statistics 21 using ANOVA with a p value of ≤0.05 regarded as significant.ResultsHormonal analysis shows that cortisol levels in the vasovagal, postural tachycardia syndrome and in control group was 153±16.7pg/ml, 160.17±pg/ml, and 69.65± 5.8pg/ml respectively. Cortisol levels were significantly higher in both vasovagal and POTS groups as compared to controls with a p-value of 0.04 and 0.023 respectively. However, there was no significant difference between vasovagal and POTS patients with p value 0.570.ConclusionIt is concluded from the study that cortisol responses of VVS and POTS were positive.Copyright: © Pakistan Journal of Medical Sciences.

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