• George N Baison, Anee S Jackson, Candice L Wilshire, BellReginald C WRCWInstitute of Esophageal and Reflux Surgery, Englewood, CO., Veronica Lazzari, Luigi Bonavina, Shahin Ayazi, Blair A Jobe, Sebastian F Schoppmann, Colin P Dunn, John C Lipham, Christy M Dunst, Alexander S Farivar, Adam J Bograd, and Brian E Louie.
• Swedish Cancer Institute, Seattle, WA.
• Ann. Surg. 2023 Apr 1; 277 (4): e793e800e793-e800.

ObjectiveTo evaluate and characterize outcomes of MSA in patients with IEM.Summary Background DataMSA improves patients with gastroesophageal reflux and normal motility. However, many patients have IEM, which could impact the outcomes of MSA and discourage use.MethodsAn international, multi-institutional case control study of IEM patients undergoing MSA matched to normal patients was performed. Primary outcomes were new onset dysphagia and need for postoperative interventions.ResultsA total of 105 IEM patients underwent MSA with matching controls. At 1 year after MSA: GERD-Health Related Quality of Life was similar; DeMeester scores in IEM patients improved to 15.7 and 8.5 in controls ( P = 0.021); and normalization of the DeMeester score for IEM = 61.7% and controls = 73.1% ( P = 0.079).In IEM patients, 10/12 (83%) with preop dysphagia had resolution; 11/66 (17%) had new onset dysphagia and 55/66 (83%) never had dysphagia. Comparatively, in non-IEM patients, 22/24 (92%) had dysphagia resolve; 2/24 (8%) had persistent dysphagia; 7/69 (10%) had new onset dysphagia, and 62/69 (90%) never had dysphagia.Overall, 19 (18%) IEM patients were dilated after MSA, whereas 12 (11%) non-IEM patients underwent dilation ( P = 0.151). Nine (9%) patients in both groups had their device explanted.ConclusionsPatients with IEM undergoing MSA demonstrate improved quality of life and reduction in acid exposure. Key differences in IEM patients include lower rates of objective GERD resolution, lower resolution of existing dysphagia, higher rates of new onset dysphagia and need for dilation. GERD patients with IEM should be counselled about these possibilities.Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.

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