• Jun Li, Dan Wang, and Jingping Sun.
• Department of Gastroenterology, Clinical Medical College and the First Affiliated Hospital of Chengdu Medical College, Chengdu, China.
• Medicine (Baltimore). 2022 Jan 21; 101 (3): e28584e28584.

RationaleTransjugular intrahepatic portosystemic shunt (TIPS) is mainly used to treat acute and chronic esophageal, gastric, and intestinal variceal bleeding and refractory ascites caused by portal hypertension. The most common complication of TIPS is the development of hepatic encephalopathy (HE). Fecal microbiota transplantation (FMT) is an emerging method for treating diseases by altering the intestinal flora. We present 2 cases of FMT that ameliorated liver function and HE after TIPS.Patient ConcernsIn this report, 2 patients with liver cirrhosis secondary to hepatitis B had recurrent Grade 2-3 HE after TIPS.DiagnosisTwo patients were diagnosed as having HE.InterventionsThe 2 patients separately received 3 times of FMT.OutcomesThe liver function of both patients improved, the clinical symptoms were relieved, and the number of HE attacks decreased significantly after FMT.LessonsFMT may be another effective way to treat HE, and is worthy of further research.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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