• Leandro Ryuchi Iuamoto, Fábio Luis Kenji Ito, Thales Augusto Tomé, Wu Tu Hsing, Alberto Meyer, Marta Imamura, and Linamara Rizzo Battistella.
• Centro de Pesquisa Clinica, Instituto de Medicina Fisica e Reabilitacao, Hospital das Clinicas HCFMUSP, University of Sao Paulo School of Medicine, Sao Paulo, SP, Brazil.
• Medicine (Baltimore). 2022 Jan 21; 101 (3): e28616e28616.

BackgroundKnee osteoarthritis (OA) is associated with chronic inflammation in somatic structures, which alters sensory afferents and leads to plastic changes in the nervous system.MethodsA systematic literature review was carried out, without language restrictions, period, or status of publication. The database used were Medline, EMBASE, Cochrane Library and clinicaltrials.gov. Extra bibliographic references were extracted through the discussion with specialists, and through scientific researches in conference papers.ResultsThe electronic search found 938 articles. When excluding duplicates and applying the inclusion/exclusion criteria, 5 studies were considered: 2 using EEG and 3 using TMS. Significant reduction of EEG activity in the cingulate medium cortex, reduction of conditioned pain modulation (CPM) in studies with EEG, as well as the occurrence of an association between pain and motor response threshold/intracortical pain facilitation in studies with TMS were observed.ConclusionsThe study contributes to a better understanding of the neurophysiological changes seen in the cingulate medium cortex, decrease in CPM and motor response threshold/intracortical pain facilitation. Advances in neuroplasticity studies may aid in the screening for early diagnosis of knee OA in the future. However, more studies are necessary.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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