• Ning Luo, Rongrong Li, Yiyi Wang, Yunfan Xia, Jing Sun, Linfang Zhao, Chao Sun, Jiemin Sun, and Jianqiao Fang.
• The Third Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou City, Zhejiang Province, China.
• Medicine (Baltimore). 2022 Jan 21; 101 (3): e28631e28631.

BackgroundPatients with trigeminal neuralgia (TN) often develop a terrible fear of triggering pain, which may lead to anxiety and depression, exerting a negative effect on their quality of life. This protocol is carried out to comprehensively explore the effectiveness and safety of acupuncture for treating anxiety and depression induced by TN.MethodsRandomized control trials involving acupuncture for treating patients with anxiety and depression caused by TN will be searched in eight electric databases, including PubMed, Web of Science, EMBASE, Cochrane Central Register of Controlled Trials, Chinese National Knowledge Infrastructure, Chinese Biomedical Literature Database, Wanfang Database and Technology Periodical Database (VIP). In addition, studies that were reported in Chinese or English will be considered. Studies selection, data extraction and risk of bias assessment of the included studies will be conducted independently by two reviewers. Quality of the included studies will be performed according to the Cochrane Risk of Bias tool. Meanwhile, the level of evidence for results will be assessed by using the Grading of Recommendations Assessment, Development, and Evaluation method. The primary outcomes will be the Hamilton Anxiety/Depression Scale or Zung Self-Rating Anxiety/Depression Scale, secondary outcomes will be the visual analog score, numerical rating score, SF-36, and adverse events. All analyses will be conducted by using the RevMan software V5.3.ResultsA high-quality synthesis of current evidence of acupuncture for TN patients associated with anxiety and depression will be provided in this study.ConclusionThis systematic review will offer comprehensive evidence of acupuncture on specific outcomes induced by TN and TN-related anxiety and depression.Trial RegistrationPROSPERO registration number: CRD42020219775.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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