• Dong Hyung Lee, Jong Kil Joo, Dong Soo Suh, Byung Sup Shin, Seo Yoon Hwang, and Ki Hyung Kim.
• Department of Obstetrics and Gynecology, Pusan National University School of Medicine, Busan, Republic of Korea.
• Medicine (Baltimore). 2022 Jan 21; 101 (3): e28664e28664.

RationaleCervical cancer complicated by irreducible complete uterine prolapse in elderly patients is extremely rare. No standard treatment has been established for these conditions.Patient ConcernsA 74-year-old woman with a 30-year history of pelvic organ prolapse presented with irreducible complete uterine prolapse and a large exophytic mass involving the cervix and vaginal wall.DiagnosisBiopsy of the mass was performed at the referring institution and showed invasive verrucous-type squamous cell carcinoma.InterventionsA prolapsed uterus with a tumor mass could not be manually reduced. After completion of concurrent chemoradiotherapy, the tumor mass in the prolapsed uterus decreased and could be reduced manually. Subsequently, the patient underwent hysterectomy and intra-abdominal uterosacral ligament suspension.OutcomesAt 19 months of postoperative follow-up, the patient remained disease-free and had no evidence of vault prolapse.LessonsThis study has important clinical implications and may provide a therapeutic strategy to address unmet medical needs in combination with locally advanced cervical cancer complicated by irreducible complete uterine prolapse. These conditions were successfully treated using a multidisciplinary approach of chemoradiotherapy followed by radical hysterectomy and uterosacral ligament suspension.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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