• British medical bulletin · Dec 2017

    Review

    Faecal transplantation for IBD management-pitfalls and promises.

    • M N Quraishi, T Critchlow, N Bhala, N Sharma, and T Iqbal.
    • Department of Gastroenterology, Queen Elizabeth Hospital Birmingham, Mindelsohn Way, Birmingham B15 2TH, UK.
    • Br. Med. Bull. 2017 Dec 1; 124 (1): 181-190.

    BackgroundFaecal microbiota transplantation (FMT) as a potential treatment for inflammatory bowel disease (IBD) is an area of active current research, having been stimulated by the remarkable efficacy of FMT in treatment of Clostridium difficile-associated colitis.Sources Of DataThis review is based on data from numerous case series on FMT in IBD since 1989 and results of four RCTs in ulcerative colitis (UC); three fully published.Areas Of AgreementEarly signals of short to medium-term efficacy of FMT for UC are promising.Areas Of ControversyMethodology, underlying mechanisms and questions regarding safety of FMT remain controversial.Growing PointsMany trials of FMT in adults and children are currently recruiting.Areas Timely For Developing ResearchFuture trials of FMT will likely revisit Crohn's disease and patients undergoing pouch surgery. Advances in microbial culture complementing genetic sequencing and investigations into the virome and mycobiome in IBD will be of great future interest.© The Author 2017. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

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