• J Coll Physicians Surg Pak · Feb 2022

    Randomized Controlled Trial

    Effect of Fresh Gas Flow Rate on Thiol/Disulphide Hemostasis and Ischemia-modified Albumin in Laparoscopic Cholecystectomy.

    • Sermin Eminoglu, Seyda Efsun Ozgunay, Umran Karaca, Asiye Demirel, Mehmet Gamli, Yasemin Ustundag, Derya Karasu, Hasan Eroglu, and Ozcan Erel.
    • Department of Anaesthesiology and Reanimation, Health Science University, Bursa Yuksek Ihtisas Training and Education Hospital, Bursa, Turkey.
    • J Coll Physicians Surg Pak. 2022 Feb 1; 32 (2): 141-146.

    ObjectiveTo investigate the effects of low-flow and high-flow anesthesia techniques, administered with sevoflurane during laparoscopic cholecystectomy, on thiol/disulphide homeostasis and serum ischemia-modified albumin (IMA) levels.Study DesignDouble-blind, randomised study.Place And Duration Of StudyDepartment of Anesthesiology and Reanimation, Health Science University, Bursa Yuksek Ihtisas Training and Education hospital, Bursa, Turkey from January to October 2020.MethodologyPatients over the age of 18 years, scheduled for elective laparoscopic cholecystectomy, were included in the study. The patients were divided into two groups: Group 1 (low-flow, 1 L/min) and Group 2 (high-flow, 2 L/min). The blood samples for thiol/disulphide homeostasis and serum IMA levels were collected as follows: 5 minutes before induction of anesthesia (T0), 5 minutes after induction of anesthesia (T1) and postoperative 24th hour (T2).ResultsThe final analysis included 104 patients. The two groups did not differ significantly in terms of any of the demographic characteristics (p >0.05). There were also no inter-group differences in terms of thiol/disulphide homeostasis parameters or serum IMA levels at T0, T1, or T2. However, in both groups, there were statistically significant changes in serum disulphide and IMA levels from T0 to T1 and T0 to T2 (p=0.000, and p=0.005, respectively).ConclusionThere was no difference between low-flow and high-flow anesthesia during laparoscopic cholecystectomy in terms of hemodynamics or thiol/disulphide homeostasis. Key Words: Low-flow anesthesia, High-flow anesthesia, Thiol/disulphide homeostasis, İschemia-modified albumin (IMA), Laparoscopic cholecystectomy.

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