• SimsekEda TanrikuluETDepartment of Medical Oncology, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey., Ezgi Coban, Elif Atag, Serkan Gungor, Fugen Aker, and Murat Sari.
• Department of Medical Oncology, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey.
• J Coll Physicians Surg Pak. 2022 Feb 1; 32 (2): 181-185.

ObjectiveTo evaluate the effect of FDG-PET/CT in the radiological imaging of breast cancer (BC) patients planned for neoadjuvant treatment (NAT), on the clinical prognostic stage (CPS).Study DesignA descriptive study.Place And Duration Of StudyHaydarpasa Numune Training and Research Hospital, Istanbul, Turkey, between June 2014 and September 2020.MethodologyConsecutive patients with stage I-III breast cancer (BC) who were planned for neoadjuvant treatment (NAT). The distribution of CPS detected by both conventional radiological methods (c-CPS) and FDG-PET/CT (PET-CPS) were compared.ResultsSignificant upstaging on CPS was detected with the addition of FDG-PET/CT to conventional imaging methods in 25/121 (20.7%) patients (p <0.001). In the c-CPS stage, IB, IIA, IIB, IIIA, IIIB patients, the stage change rate was 22.7%, 28.6%, 37.5%, 50%, and 9.1%, respectively. There was no change in patients with c-CPS stage IA and IIIC. There was a significant change in the cN stages (p <0.001), while no significant change was detected in the cT stages of the patients (p = 0.180). Upstaging was detected in 5/16 (6.3%, p=0.034), 14/71 (19.7%, p <0.01), 15 / 30 (50%, p <0.01) of initially cN 0, 1, 2 patients, respectively (p<0.001).ConclusionThe change in CPS was due to nodal upstaging. The effectiveness of including FDG-PET/CT in the initial radiological imaging in patients planned for NAT should be evaluated with prospective studies evaluating treatment choices to be used in NAT. Key Words: PET scan, Breast cancer, Positron emission tomography, Neoadjuvant treatment, Cancer staging, Staging system, TNM.

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