• Gac Med Mex · Jan 2021

    Matrix metalloproteinases 7, 8, 12, 13 gene haplotypes associated with colorectal cancer in a Mexican population.

    • José M Moreno-Ortiz, Melva Gutiérrez-Angulo, Ruth Ramírez-Ramírez, Anahí González-Mercado, Alexis S Suárez-Villanueva, Miriam Partida-Pérez, Víctor Maciel-Gutiérrez, and Ma de la Luz Ayala-Madrigal.
    • Department of Molecular Biology and Genomics, Instituto de Genética Humana Dr. Enrique Corona Rivera, University Center of Health Sciences, Universidad de Guadalajara.
    • Gac Med Mex. 2021 Jan 1; 157 (5): 531-536.

    BackgroundMatrix metalloproteinases (MMPs) are involved in tumor invasion and progression in colorectal cancer (CRC). Variants rs11568818, rs11225395, rs2276109 and rs2252070 have been associated with this neoplasm.ObjectiveTo evaluate MMPs 7, 8, 12, and 13 haplotypes and their association with CRC.Material And MethodsOne-hundred and four patients and 112 healthy individuals were genotyped by polymerase chain reaction-restriction fragment length polymorphism analysis (PCR-RFLP). For the association analysis, odds ratio and confidence interval values were calculated. Haplotype and linkage disequilibrium (LD) analysis was performed with Arlequin software, v3.5.ResultsLD was present between rs2276109 and rs2252070. Haplotypes rs11568818(A)-rs11225395(T)-rs2276109(A)-rs2252070(A) and rs11568818(A)-rs11225395(C)-rs2276109(A)-rs2252070(G) were associated with CRC risk, and haplotypes rs11568818(G)-rs11225395(C)-rs2276109(A)-rs2252070(A) and rs11568818(A)-rs11225395(T)-rs2276109(A)-rs2252070(G), with protection.ConclusionVariants rs2276109 and rs2252070 showed genetic linkage. Two haplotypes were associated with the development of CRC (ATAA and ACAG) and two were associated with protection (GCAA and ATAG). This study represents the first report on variants rs11225395 and rs2276109 frequency in a Mexican population.Copyright: © 2021 Permanyer.

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