• Mirthala Flores-García, Juan M Fernández-González, Mireille León-Martínez, Simón Hernández-Ortega, José R Hernández-López, Daniela Reyes-Munguía, Hugo Sánchez-Sarabia, Zeuz Piña-Fragoso, and Aurora de la Peña-Díaz.
• Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez.
• Gac Med Mex. 2021 Jan 1; 157 (6): 588-593.

BackgroundEstrogens that are used as contraceptives or in replacement therapy are associated with an increase in the risk for developing thrombosis, mainly during the first year of treatment and in women with associated risk factors.ObjectiveTo synthesize, characterize and identify the anticoagulant, antiplatelet aggregation and microvesicle-reducing effect of the new aminoestrogen Tyrame.Material And MethodsCD1 strain mice were used, which had Tyrame (0, 1 and 2 mg/100 g) subcutaneously administered. At 24 h, a blood sample was obtained to determine whole-blood clotting time, microvesicles concentration and inhibitory effect on platelet aggregation.ResultsBlood clotting time increased up to 1.5 times in comparison with the control. Platelet aggregation inhibition had different magnitude depending on the agonist agent employed, and was complete with collagen. Both effects had a dose-dependent relationship. The microvesicles decreased up to six times with respect to the control.ConclusionsTyrame reduces platelet aggregation and microvesicle formation, which emphasizes its potential therapeutic utility as an estrogen free of thrombotic effects.Copyright: © 2021 Permanyer.

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