• Gac Med Mex · Jan 2021

    Association between cardiometabolic comorbidities and Parkinson's disease in a Mexican population.

    • Amin Cervantes-Arriaga, Óscar Esquivel-Zapata, Emmanuel Escobar-Valdivia, David García-Romero, Ángel Alcocer-Salas, and Mayela Rodríguez-Violante.
    • Movement Disorders Clinic.
    • Gac Med Mex. 2021 Jan 1; 157 (6): 624-629.

    BackgroundThe prevalence of Parkinson's disease (PD) increases as the population ages. Studies have shown that some cardiometabolic comorbidities could be associated with risk or protection against developing PD. A retrospective case-control study was carried out to analyze the relationship between PD and cardiometabolic comorbidities.Material And MethodsSubjects with PD and controls without PD were consecutively recruited. Data on type 2 diabetes mellitus, systemic arterial hypertension (SAH), dyslipidemia and body mass index were collected. Logistic regression analyses were carried out.ResultsA total of 781 subjects with PD (56.5% males) and 1,000 controls (44.4% males) were included. After adjusting for age and gender, SAH was found as an independent risk factor (OR: 1.32; 95% CI: 1.05-1.67; p = 0.02), and obesity as a protective factor (OR: 0.72; 95% CI: 0.56-0.93; p = 0.01).ConclusionsSubjects with SAH had a higher risk of having PD, while obese subjects had a lower risk of having PD. The relationship between cardiometabolic disease, its treatment, and PD etiopathogenesis appears to be extremely complex given the amount of contradictory data.Copyright: © 2021 Permanyer.

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