• Otoniel Toledo-Salinas, Luis A Sánchez-Hurtado, and Juan Rodríguez-Silverio.
• Specialty Hospital, Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social.
• Gac Med Mex. 2021 Jan 1; 157 (4): 377-383.

IntroductionWhether fever and antipyretic treatment are related to progression of organ dysfunction (POD) in sepsis is currently not known.ObjectiveTo evaluate the association of fever and antipyretic treatment with POD in sepsis.MethodsProspective cohort study of patients with sepsis. Maximum axillary temperature (T° Max), antipyretic drugs total dose and daily SOFA score were recorded. POD was defined as an increase ≥ 1 point on the SOFA score. A multivariate logistic regression model was used to evaluate the studied association.Results305 patients were included: 163 were women (53.4%), with a SOFA score of 8 points (6-11); 130 participants (42.62%) had T° Max ≥ 38°C, and 76 (24.9%), POD. Mortality in patients with fever was 26.2% vs. 20% (p = 0.21), and with POD, 73.7% vs. 5.7% (p = 0.01). T° Max ≥ 39°C had an OR of 4.96 (95% CI = 1.97-12.47, p = 0.01); and the use of antipyretics, an OR of 1.04 (95% CI: 0.58-1.86, p = 0.88).ConclusionsAn axillary T° Max ≥ 39°C is a risk factor for POD in sepsis. The use of antipyretics was not associated with POD.Copyright: © 2021 Permanyer.

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