• Qiying Song, Mengying Wang, Tao Zhou, Dianjianyi Sun, Hao Ma, Xiang Li, Yoriko Heianza, and Lu Qi.
• Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA; Maternal-Fetal Medicine Institute, Shenzhen Baoan Women's and Children's Hospital, Jinan University, Shenzhen; Department of Maternal and Child Health, School of Public Health, Peking University, Beijing, China.
• Mayo Clin. Proc. 2022 Mar 1; 97 (3): 519530519-530.

ObjectiveTo prospectively assess whether sleep patterns modified lifestyle-associated cardiovascular disease (CVD) risk.Patients And MethodsThis study included 393,690 participants without CVD at baseline measurements between March 13, 2006, and October 1, 2010, from UK Biobank. A lifestyle score was calculated on the basis of the 4 lifestyle factors (smoking, alcohol consumption, physical activity, and diet), and sleep patterns were constructed based on sleep duration, chronotype, insomnia, snoring, and daytime dozing.ResultsDuring a median follow-up of 8.93 years, we observed 10,218 incident CVD events, including 6595 myocardial infarctions (MIs) and 3906 strokes. We found that sleep patterns significantly modified the relations of the lifestyle score with incident CVD (P for interaction =.007) and MI (P for interaction =.004). Among participants with a poor sleep pattern, unfavorable lifestyle (per score increase) was associated with 25% (95% CI, 13% to 39%) and 29% (95% CI, 13% to 47%) increased risks for CVD and MI, while among participants with a healthy sleep pattern, unfavorable lifestyle was associated with 18% (95% CI, 15% to 21%) and 17% (95% CI, 13% to 21%) increased risks for CVD and MI.ConclusionOur results indicate that adherence to a healthy sleep pattern may attenuate the CVD risk associated with an unfavorable lifestyle.Copyright © 2021 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

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