• Megan L Rolfzen, Susan K Mikulich-Gilbertson, Crystal Natvig, Jacqueline A Carrico, Robert L Lobato, Martin Krause, and Karsten Bartels.
• Department of Anesthesiology, University of Nebraska Medical Center, Omaha, NE, USA.
• J Clin Anesth. 2022 Jun 1; 78: 110674.

Study ObjectiveIn the United States, alcohol use disorder adversely affects 5.6% of all adults. Excessive alcohol consumption adversely affects organ functions critical for adaptation to stress induced by surgery. Colorectal resection is one of the most common major surgeries in patients at risk for alcohol use disorder. The objective of this study was to assess the impact of alcohol use disorder on hospital outcomes after colectomy using a population-based discharge database.SettingPopulation-based discharge database.PatientsThe Premier Healthcare Database was queried for the 603,730 adult patients who underwent colectomy from 2016 to 2019.InterventionsNone.MeasurementsMultiple logistic regressions estimated the associations between in-hospital mortality, length of stay, and hospitalization cost with alcohol use disorder as the primary predictor, adjusting for other substance use disorders, psychotic disorders, depression, other Elixhauser comorbidities, age, payor, race, gender, non-elective surgery, and other unbalanced variables.Main ResultsA discharge code for alcohol use disorder was identified in 2.9% of colectomy patients and the overall in-hospital mortality rate in all sampled colectomy patients was 1.4%. Alcohol use disorder was associated with a significantly increased risk of in-hospital mortality after adjusting for other factors (AOR 1.36, 95% CI 1.24-1.48, p < 0.0001). Alcohol use disorder was also significantly associated with long length of stay (AOR 1.45, 95% CI 1.39-1.52, p < 0.0001) and high hospitalization costs (AOR 1.63, 95% CI 1.56-1.70, p < 0.0001).ConclusionsAlcohol use disorder is associated with an increased risk of in-hospital mortality in patients undergoing colectomy, one of the most common major surgeries. Future research should examine if enhanced efforts to identify patients with alcohol use disorder could enable anesthesiologists to provide worthwhile perioperative interventions for this high-risk population.Copyright © 2022 Elsevier Inc. All rights reserved.

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