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- Pratishtha Mehra, Vimal Mehta, Jamal Yusuf, Rishi Sukhija, and Wilbert S Aronow.
- Department of Cardiology, G.B. Pant Institute of Postgraduate Medical Education and Research, India.
- Arch Med Sci. 2022 Jan 1; 18 (1): 260-266.
IntroductionEndothelin-1 (ET-1) gene polymorphisms are implicated in pathogenesis of idiopathic pulmonary arterial hypertension.MethodsWe studied ET-1 (Lys198Asn and 3A/4A) and endothelin receptor A (ETA) gene (His323His) polymorphisms in 123 subjects with pulmonary hypertension associated with rheumatic mitral valve disease (PH-MVD) and 123 healthy controls.ResultsThe mutant homozygous Asn/Asn genotype in Lys198Asn and T/T genotype in His323His polymorphism was more prevalent in the PH-MVD group. Presence of Asn/Asn genotype was significantly associated with an increased risk (odds ratio 3.9).ConclusionsET-1 and ETA gene polymorphisms are prevalent in the PH-MVD group suggesting that they may predispose to the development of PH.Copyright: © 2022 Termedia & Banach.
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