• British medical bulletin · Mar 2022

    Matrix-induced autologous chondrocyte implantation (mACI) versus autologous matrix-induced chondrogenesis (AMIC) for chondral defects of the knee: a systematic review.

    • Filippo Migliorini, Jörg Eschweiler, Christian Götze, Arne Driessen, Markus Tingart, and Nicola Maffulli.
    • Department of Orthopaedic and Trauma Surgery, RWTH University Hospital Aachen, Pauwellstr. 31, 52074 Aachen, Germany.
    • Br. Med. Bull. 2022 Mar 21; 141 (1): 47-59.

    IntroductionChondral defects of the knee are common and their treatment is challenging.Source Of DataPubMed, Google scholar, Embase and Scopus databases.Areas Of AgreementBoth autologous matrix-induced chondrogenesis (AMIC) and membrane-induced autologous chondrocyte implantation (mACI) have been used to manage chondral defects of the knee.Areas Of ControversyIt is debated whether AMIC and mACI provide equivalent outcomes for the management of chondral defects in the knee at midterm follow-up. Despite the large number of clinical studies, the optimal treatment is still controversial.Growing PointsTo investigate whether AMIC provide superior outcomes than mACI at midterm follow-up.Areas Timely For Developing ResearchAMIC may provide better outcomes than mACI for chondral defects of the knee. Further studies are required to verify these results in a clinical setting.© The Author(s) 2022. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

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