• World Neurosurg · May 2022

    Randomized Controlled Trial

    Assessment of Patients' Willingness to Participate in a Randomized Trial of Spinal versus General Anesthesia for Lumbar Spine Surgery.

    • Gaetano De Biase, Selby Chen, Endrit Ziu, Diogo Garcia, Elird Bojaxhi, Rickey E Carter, Alfredo Quinones-Hinojosa, and Kingsley Abode-Iyamah.
    • Department of Neurosurgery, Mayo Clinic, Jacksonville, Florida, USA.
    • World Neurosurg. 2022 May 1; 161: e635-e641.

    BackgroundProspective nonrandomized studies have found less postoperative fatigue and improved quality of life in patients undergoing awake spine surgery under spinal anesthesia compared with general anesthesia. Randomized trials are needed to validate these findings.ObjectiveTo prospectively investigate patients' willingness to enroll in randomized trials of lumbar spine surgery under spinal versus general anesthesia and identify any potential barriers.MethodsWe recruited patients undergoing lumbar spine surgery for degenerative disease. We described a randomized trial of spine surgery under spinal versus general anesthesia and assessed patients' willingness to participate in such trial. We elicited preferences for treatment along with demographics. The association between these factors and willingness to participate in the trial was examined.ResultsFifty patients completed interviews; 58% were female, mean age of 60.9 ± 12.5 years. A total of 52% patients stated that they were definitely willing to participate in the hypothetical randomized trial, and 8% probably willing. Only 16% of patients were aware of spinal anesthesia as an option for low back surgery, and 60% indicated no strong preference for the anesthesia techniques. Patients without strong preferences stated a greater willingness to participate than those with strong preferences (80% vs. 10% definitely willing, P < 0.0001). Age, sex, education, work status, and race were not significantly associated with willingness to participate.ConclusionSixty percent of patients stated that they were either definitely or probably willing to participate in the randomized trial. Subjects lacking strong preferences for the anesthesia technique stated a greater willingness to enroll than those with strong preference.Copyright © 2022 Elsevier Inc. All rights reserved.

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