• Medicina · Jan 2022

    Review

    MDR Tuberculosis Treatment.

    • Juan Espinosa-Pereiro, Adrian Sánchez-Montalvá, Maria Luisa Aznar, and Maria Espiau.
    • Infectious Diseases Department, Vall d'Hebron University Hospital, PROSICS Barcelona, Universitat Autònoma de Barcelona, 08135 Barcelona, Spain.
    • Medicina (Kaunas). 2022 Jan 26; 58 (2).

    AbstractMultidrug-resistant (MDR) tuberculosis (TB), resistant to isoniazid and rifampicin, continues to be one of the most important threats to controlling the TB epidemic. Over the last few years, there have been promising pharmacological advances in the paradigm of MDR TB treatment: new and repurposed drugs have shown excellent bactericidal and sterilizing activity against Mycobacterium tuberculosis and several all-oral short regimens to treat MDR TB have shown promising results. The purpose of this comprehensive review is to summarize the most important drugs currently used to treat MDR TB, the recommended regimens to treat MDR TB, and we also summarize new insights into the treatment of patients with MDR TB.

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