• Lidia Glodzik-Sobanska, Henry Rusinek, Lisa Mosconi, Yi Li, Jiong Zhan, Susan de Santi, Antonio Convit, Kenneth Rich, Miroslaw Brys, and Mony J de Leon.
• Center for Brain Health, New York University School of Medicine, New York, NY 10016, USA.
• Neuroimaging Clin. N. Am. 2005 Nov 1; 15 (4): 803-26, x.

AbstractThe goal of this article is to review the role of structural neuroimaging in the diagnosis of Alzheimer's disease (AD). We present relevant neuroanatomy, highlight progress in the domain of AD imaging, and review the clinical characteristics of the prodromal phase of AD. We describe the history of the diagnostic issue by examining at cross-section and longitudinally the differences between patients who have AD and normal controls. We also present how subsequent works applied these characteristic traits to the early detection of the prodromal disease and to prediction of future decline. The article delineates the differences between subjects who have mild cognitive impairment and AD, which illustrate the spreading of the pathology with disease progression. The last section describes problems encountered in the differential diagnosis.

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