• Karolina Łagowska, Anna M Malinowska, Karina Kapczuk, Joanna Mikołajczyk-Stecyna, Agata Chmurzyńska, and Marcin Schmidt.
• Poznań University of Life Sciences, Department of Human Nutrition and Dietetics, Poznań, Poland. Electronic address: karolina.lagowska@up.poznan.pl.
• Nutrition. 2022 May 1; 97: 111606.

ObjectivesThe aim of this study was to evaluate the relationship between β-glucuronidase and androgen levels in overweight and obese women with polycystic ovary syndrome (PCOS). The connection between β-glucuronidase, the abundance of selected gut bacteria, carbohydrate metabolism, and diet quality was also determined.MethodsThis cross-sectional study was conducted with 56 women with a mean age of 29.14 ± 5.11 y and a mean body mass index (BMI) of 34.15 ± 5.72 kg/m2. Anthropometrical parameters, fecal β-glucosidase activity, and selected food frequency intake were measured.ResultsWomen with better quality diets, apart from lower BMI and better carbohydrate metabolism parameters, had more abundant Faecalibacterium prausnitzii and Akkermansia muciniphila. Two-hour oral glucose tolerance test (OGTT-2h-glu; mg/dL) was the main predictor of β-glucuronidase activity and there was no relationship between β-glucuronidase activity and androgen levels. Non-Healthy Diet Index-14 (nHDI-14) was the main predictor for A. muciniphila, Bifidobacteriu. longum, and F. prausnitzii abundance. QUICKI was a significant predictor of A. muciniphila abundance and OGTT-2h-glu was a significant predictor of F. prausnitzii abundance.ConclusionThere was no relationship between β-glucuronidase activity and androgen levels in overweight and obese women with PCOS, but β-glucuronidase activity may be an important factor in carbohydrate metabolism. Modulation of the abundances of F. prausnitzii, A. muciniphila, and B. longum using special diets should thus be considered a promising intervention.Copyright © 2022 Elsevier Inc. All rights reserved.

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