• Presse Med · Apr 2004

    Review Comparative Study

    [Renal and cardiovascular effects of non-steroidal anti-inflammatories and selective cox 2 inhibitors].

    • Gilbert Deray.
    • Service de néphrologie, Groupe hospitalier Pitié-Salpêtrière, 83 boulevard de l'Hôpital, 75013 Paris, France. gilbert.deray@psl.ap-hop-paris.fr
    • Presse Med. 2004 Apr 10; 33 (7): 483-9.

    AbstractHYPERKALIEMIA AND RENAL FAILURE: Nonsteroidal anti-inflammatory drugs (NSAIs) may induce hyperkaliemia and renal failure. With regard to these complications, the notion of a risk factor is fundamental. Selective cyclooxygenase-2 inhibitors (Cox-2) do not provide any notable advantages with regard to the incidence of hyperkaliemia and renal failure. OEDEMA AND BLOOD PRESSURE: The NSAIs provoke salt-water retention which is responsible for oedema in 2 to 5% of patients (here again the notion of a risk factor is important). The salt-water retention is implied in the increase in blood pressure and the decompensation of heart failure. It has been shown that the incidence of oedema and the increase in blood pressure was significantly reduced with celecoxib compared with rofecoxib. This might have a crucial impact on the mean and long term follow-up of cardiovascular risk in these patients.

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