Presse Med
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We developed a prescribing guideline containing recommendations for the initial empirical antibiotic therapy in community or nosocomial pneumonia. The aim of the present study was to examine the impact of this measure. ⋯ The use of a prescribing guideline might improve the efficiency of empirical probabilistic antibiotic therapies. The impact of the guideline use on overall antibiotic costs and microbiological flora remains to be determined.
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Review Comparative Study
[Renal and cardiovascular effects of non-steroidal anti-inflammatories and selective cox 2 inhibitors].
HYPERKALIEMIA AND RENAL FAILURE: Nonsteroidal anti-inflammatory drugs (NSAIs) may induce hyperkaliemia and renal failure. With regard to these complications, the notion of a risk factor is fundamental. Selective cyclooxygenase-2 inhibitors (Cox-2) do not provide any notable advantages with regard to the incidence of hyperkaliemia and renal failure. ⋯ The salt-water retention is implied in the increase in blood pressure and the decompensation of heart failure. It has been shown that the incidence of oedema and the increase in blood pressure was significantly reduced with celecoxib compared with rofecoxib. This might have a crucial impact on the mean and long term follow-up of cardiovascular risk in these patients.
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Henoch-Schonlein purpura (HSP) is a small vessel leucocytoclastic vasculitis with IGA deposit. Its little known underlying pathogenic mechanism probably involves an auto-immune reaction triggered-off by various antigens and notably bacterial or viral infectious agents. ⋯ The association of a tuberculosis with HSP is very rarely reported in children. The underlying pathogenic mechanisms are not yet clear. It can be triggered-off by tuberculosis or antituberculosis treatment. In our patient, the rapid regression of the symptomatology and pursuit of the treatment without incidents argue against the hypothesis of HSP induced by antituberculosis agents.