• Yesim Yildirim, Yesim Akcay, Ozgur Ozyilkan, and Bulent Celasun.
• Department of Medical Oncology, Baskent University, Ankara, Turkey. dryesimyildirim@yahoo.com
• Med Princ Pract. 2008 Jan 1; 17 (3): 250-2.

ObjectivesTo report a rare case of small cell carcinoma of the prostate with unusual skin metastasis.Clinical Presentation And InterventionsA 60-year-old was evaluated for difficulty in urinating. Abdominal computed tomography scans revealed a prostatic mass invading the surrounding tissues and multiple perirectal, periprostatic, para-aortic and pericaval lymph nodes. Needle biopsy specimens showed both small cell carcinoma and adenocarcinoma. He was treated with combination chemotherapy: cisplatin and etoposide and bilateral orchiectomy. After six cycles of the chemotherapy, disease progressed and the patient did not respond to salvage therapy; hence, palliative care was instituted. During the follow-up, papillary lesions were observed in the scrotal skin; biopsy showed metastatic small cell carcinoma.ConclusionSmall cell carcinoma of the prostate is an aggressive disease with a highly metastatic potential; but skin metastases are very uncommon. It has poor prognosis despite therapy. Management resembles that of small cell carcinoma of the lung.(c) 2008 S. Karger AG, Basel

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