• W Indian Med J · Sep 2015

    The Investigation of Plasma Glucagon-like Peptide-1 Levels in Newly Diagnosed Type 1 Diabetic Children.

    • B Uslu, F Gurbuz, F Temiz, B Yuksel, N Mungan, and A K Topaloglu.
    • Department of Pediatrics, Cukurova University, Adana, Turkey.
    • W Indian Med J. 2015 Sep 3; 65 (1): 141-146.

    ObjectiveTo reveal the possible role of glucagon-like peptide-1 (GLP-1) in newly diagnosed Type 1 diabetic children.MethodsTwenty-five newly diagnosed children and 22 healthy children were included in the study.ResultsIn oral glucose tolerance tests, no correlation was observed between C-peptide and GLP-1 levels at 0 and 30 minutes, and plasma GLP-1 levels in both groups at 0 and 30 minutes were not statistically different.ConclusionConsequently, fasting and postprandial GLP-1 levels in newly diagnosed Type 1 diabetic children are not different from healthy children. Glucagon-like peptide-1 levels in newly diagnosed Type 1 diabetic children suggest that plasma GLP-1 levels do not have any role in the pathogenesis of Type 1 diabetes mellitus.

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