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- X Wang, Y Ning, L Wang, J Zhang, Y Wang, and H Shen.
- Department of Rheumatology, the Second Hospital of Lanzhou University, Lanzhou 730030, China.
- W Indian Med J. 2016 Apr 4; 65 (2): 398-400.
ObjectiveThis study aims to observe the clinical efficacy of low-dose rituximab in patients with cryoglobulinaemia secondary to connective tissue diseases.MethodsRituximab (100 mg) was infused in patients once a week for four weeks, combined with prednisone (20 mg) once a day, and reduced regularly. Treatment effect was observed regularly.ResultsJoint pain, fever, rash and fatigue symptoms in patients eased. The serology (globulin, erythrocyte sedimentation rate, C-reactive protein, lactate dehydrogenase and others) parameters returned to normal.ConclusionLow-dose rituximab therapy for cryoglobulinaemia secondary to connective tissue diseases was safe and effective, and can be used as a treatment option in this condition.
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