• Xiao-Yan Yang, Ling Jiang, Rong-Fei Jia, and An-Ji Hou.
• Shanghai Xuhui District Center Hospital, Shanghai, China.
• Medicine (Baltimore). 2017 Sep 1; 96 (39): e8121.

RationaleWe report our experience with 2 patients diagnosed with grey zone lymphoma (GZL). The histopathological characteristics of lymphomatous tissues in these patients ranged between those of diffuse large B-cell lymphoma (DLBCL) and the classical Hodgkin lymphoma.Patient ConcernsA 52-year-old female presented to the hospital with a history of lower abdominal pain of metastatic origin for 2 days. She was diagnosed with acute appendicitis and had undergone emergency surgery. A 17-year-old male was admitted to the hospital because of acute left upper abdomen pain.DiagnosesBoth patients are diagnosed of GZL primarily based on histopathology.InterventionsBoth patients were treated with R-CODOX-M/R-IVAC regimen for 4 to 6 cycles.OutcomesThe short-term curative effect was complete response; no recurrence was observed as of 32-month follow-up.LessonsR-CODOX-M/IVAC regimen exhibited relatively good curative effect. International Prognostic Index score and lactate dehydrogenase level may correlate with prognosis of these patients.

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