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- Livia Asan, Ulrike Bingel, and Angelika Kunkel.
- Klinik für Neurologie und Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Unversitätsmedizin Essen, Hufelandstraße 55, 45147, Essen, Deutschland. livia.asan@uk-essen.de.
- Schmerz. 2022 Jun 1; 36 (3): 205212205-212.
BackgroundThe efficacy of pain therapies can be substantially modulated by treatment expectations, which is reflected by the substantial placebo effects observed in pain (so called placebo analgesia).QuestionWhat is currently known about the neurobiological and neurochemical mechanisms underlying placebo analgesia?Materials And MethodsA focused presentation of key publications in the field embedded in a structured overview of the mechanistic concepts and current theories according to recent evidence.ResultsExperimental studies with functional neuroimaging showed that the effect of placebo analgesia is reflected by changes in brain activity related to pain processing and cognitive control. The important neurotransmitters involved include opioids and dopamine.ConclusionPlacebo analgesia is associated with complex neurobiological and -physiological mechanisms. An advanced comprehension of these processes should be applied to optimize existing and future therapeutic approaches in pain therapy.© 2022. The Author(s).
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