• Bratisl Med J · Jan 2022

    Acute phase of COVID-19 is associated with elevated plasmablasts in the blood.

    • Ondrej Beran, Katerina Matuskova, Zofia Bartovska, Oldrich Bartos, and Michal Holub.
    • Bratisl Med J. 2022 Jan 1; 123 (4): 244-247.

    ObjectivesThe study was aimed at the characterization of humoral immunity in acute SARS-CoV-2 infection.BackgroundHumoral immunity plays a central role in the protection from infection due to SARS-CoV-2, causative agent of coronavirus diseases 2019 (COVID-19).Patients And MethodsIn 24 adult patients hospitalized with COVID-19, the functional subsets of circulating B-lymphocytes and SARS-CoV-2 specific IgA and IgG antibodies were analyzed using a flow cytometry and immunoassays, respectively.ResultsCirculating plasmablasts and memory B-lymphocytes were significantly elevated and regulatory B-lymphocytes significantly decreased in the patients in comparison with 11 age- and sex-matched SARS-CoV-2 seronegative healthy adults. Next, circulating plasmablasts correlated negatively with the levels of SARS-CoV-2 specific IgG antibodies, which were detectable in 9 out of 15 tested patients. In addition, SARS-CoV-2 specific IgA antibodies were detectable in 13 of 15 tested patients and did not demonstrate correlation with any B-lymphocyte subset.ConclusionSevere course of COVID-19 is associated with significant changes of phenotypes of circulating B-lymphocytes and elevated circulating plasmablasts correlate with decreased SARS-CoV-2-specific IgG antibodies (Tab. 2, Fig. 3, Ref. 14).

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