• Tiyani E Mabunda, Nalezani J Ramalivhana, and Yoswa M Dambisya.
• Limpopo Provincial Department of Health, Polokwane 0700; South Africa.
• Afr Health Sci. 2014 Dec 1; 14 (4): 849-54.

BackgroundSouth Africa has a high tuberculosis burden, and Limpopo Province experienced higher than national average TB mortality rates between 1997 and 2008.ObjectiveTo establish factors associated with TB mortality in Limpopo Province in 2008.DesignRetrospective study using provincial data for patients who died after commencing TB treatment between 01 January 2008 and 31 December 2008.ResultsIn 2008, some 18074 patients started treatment: 15995 (88.5%) had pulmonsry TB (PTB), while 2079 (11.5%) had Extra pulmonary TB (EPTB). Overall, 2242 (12.4%) patients died, mainly PTB patients (n=1906; 85%), more males (n=1159, 51.7%), mainly those aged 25 to 54 years (n=1749, 78.0%), and new cases (1914; 85.4%). TB mortality was significantly higher among smear negative than smear positive patients (17% vs 13.8%; P<0.001), among those with EPTB compared to PTB patients (P<0.001), and among re-treatment cases (P<0.001). Only 4237 (23.4%) patients had HIV status known, with higher mortality found among HIV positive than the HIV negative patients (P<0.0001); but HIV status was not known for the majority who died (n=1685, 75.2%).ConclusionHigher mortality was associated with age 22-55 years; smear negativity, EPTB, HIV infection, and re-treatment. The findings call for greater integration of TB control efforts and HIV services, especially among the 22-55 year age group.

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