• Hongyan Zang, Lianping He, Yan Chen, Jianfeng Ge, and Yingshui Yao.
• Hongyan Zang, Women's health department, Yancheng Maternal and Child Health Hospital, Yancheng 224400, Jiangsu, People's Republic of China.
• Afr Health Sci. 2016 Mar 1; 16 (1): 97-104.

ObjectiveThis study aims to evaluate the association of depression with menopausal status and some menopause symptoms (vasomotor symptoms and poor sleep).MethodsA total of 743 participants aged 40-60 years were recruited. Depression status was evaluated by using Self-Rating Depression Scale (SDS). Sleep quality and vasomotor symptoms were evaluated by specific symptoms questionnaire.ResultsThe prevalence of depression among participants was 11.4%. Depression was found more likely to occur in participants with poor sleep (OR, 6.02; 95%CI, 3.61, 10.03) or with vasomotor symptoms (VMS) (OR, 2.03; 95%CI, 1.20, 3.44) after controlling for age, education level, marital status, menopause status, monthly family income and chronic diseases. Menopause status was not associated with depression. Stratification analysis showed a significant association between poor sleep and depression across different menopause stages, while VMS were associated with depression only in premenopausal status.ConclusionThe majority of Chinese rural midlife women do not experience depression. The relationship between depression, VMS and sleep disturbances tends to change with menopausal status in Chinese rural midlife women.

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