• Chinese medical journal · Sep 2018

    Review

    Peripheral T-cell Lymphomas: Updates in Allogeneic Hematopoietic Stem Cell Transplantation.

    • Wen-Rong Huang and Dai-Hong Liu.
    • Department of Hematology, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
    • Chin. Med. J. 2018 Sep 5; 131 (17): 2105-2111.

    ObjectivePeripheral T-cell lymphomas (PTCLs) confer dismal prognosis and no consensus has been established on the role of allogeneic hematopoietic stem cell transplantation (allo-HSCT) due to its rarity and heterogeneity. The purpose was to review key points of allo-HSCT for PTCLs, including indication, times of transplantation, conditioning regimen, graft versus host disease prophylaxis, and treatment of relapse.Data SourcesA comprehensive search in PubMed and Cochrane up to February 28, 2018, with the keywords "Peripheral", "T", "Lymphoma", and "Transplantation" was done.Study SelectionRelevant articles including HSCT for PTCLs were carefully reviewed.ResultsPromising data have been reported from advances in transplant technology and more and more PTCLs patients with poor prognosis could benefit from allo-HSCT.ConclusionAllo-HSCT is a useful choice for patients with refractory/relapsed PTCLs or high-risk new diagnosed PTCLs.

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