• Wolf A Lagrèze.
• Universitäts-Augenklinik Freiburg. wolf.Lagreze@uniklinik-freiburg.de
• Dtsch Arztebl Int. 2010 Jul 1; 107 (28-29): 495-9.

BackgroundComprehensive, systematic reviews on the benefit of vision screening in preschool children were published in 2008 by major national organizations in both Germany and the United Kingdom. These reviews raised public interest in the topic.MethodsThis article contains a discussion of the sensitivity, specificity, efficacy, and cost-effectiveness of preschool vision screening, on the basis of the two national reports mentioned above as well as relevant literature retrieved by a selective PubMed search.ResultsAll studies that have been published to date on the efficacy of preschool visual screening suffer from methodological flaws. The available data suggest a benefit from screening, though this has not been proven. Model calculations reveal that the positive predictive value of screening tests performed in isolation is inadequate. The authors of the two national reports applied different methods and arrived at similar, but not identical conclusions. Preschool vision screening may also be cost-effective; whether this is the case or not depends on the probability of a long-term benefit--specifically, on the probability of preventing bilateral loss of vision in adulthood. To prevent one such case, it is estimated that 13 cases of childhood amblyopia must be identified and successfully treated (number needed to treat [NNT] = 13).ConclusionThe available data do not allow any firm conclusion about the efficacy and cost-effectiveness of preschool vision screening. Further clinical studies are needed to answer these questions.

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