• Naci Topaloglu, Adem Kucuk, Mustafa Tekin, Sule Yildirim, Mesut Erbas, Hasan Ali Kiraz, Dilek Ulker Cakir, and Havva Erdem.
• Department of Pediatrics, Çanakkale Onsekiz Mart University, Medical Faculty, Çanakkale, Turkey.
• J Coll Physicians Surg Pak. 2015 Jun 1; 25 (6): 395-8.

ObjectiveTo establish whether the Ischemia-Modified Albumin (IMA), a new parameter of oxidative stress, has diagnostic role in experimental acute pancreatitis.Study DesignRandomized controlled trial.Place And Duration Of StudyExperimental Animal Center, Çanakkale Onsekiz Mart University, Çanakkale, Turkey, from May to September 2013.MethodologySixteen Sprague-Dawley rats were randomly divided into two groups (n=8 each): Sham and AP groups. AP was induced by ligation of pancreatic duct. Serum IMA, amylase, lipase, AST, ALT and CRP were determined. The severity of pancreatitis was scored by a blinded pathologist under microscope.ResultsSerum IMA levels in the AP group increased significantly compared with the control group (p < 0.05). There was also a strong positive correlation between amylase and IMA levels.ConclusionThe present study showed in a rodent model that serum IMA might serve as an additional marker to monitor inflammation during pancreatitis.

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