• Gülbahar Darılmaz Yüce, Tuba Erdoğan, Bülent Bozkurt, Uğur Toprak, and Gülay Güleç Ceylan.
• Department of Chest Diseases, Başkent University Faculty of Medicine, Başkent Üniversitesi Tıp Fakültesi Hastanesi Göğüs Hastalıkları Anabilim Dalı, Yukarı Bahçelievler Mahallesi, Mareşal Fevzi Çakmak Caddesi, 10. Sokak No: 45, 06490, Çankaya/Ankara, Turkey. yucegulbahar@yahoo.com.tr.
• Ir J Med Sci. 2023 Feb 1; 192 (1): 269275269-275.

BackgroundAsthma is a prevalent chronic obstructive disease of the airways.AimsThe aim of our study was to investigate the relationship between asthma and IL-17F gene 74488 T > C, IL-17A gene -197G > A, and IL17A gene -737C > T polymorphisms in Turkish population.MethodsIn our study, peripheral blood samples collected from a total of 127 subjects, with 65 in the patient group and 62 in the control group, were analyzed for IL-17F gene 74488 T > C, IL-17A gene -197G > A, and IL17A gene -737C > T polymorphisms using next-generation sequencing.ResultsThere was no statistically significant relationship between IL-17A gene -197G > A and IL-17A gene -737C > T polymorphisms and the risk of developing asthma. It was found that the risk of developing asthma was 2.9-fold higher in individuals with a C allele in the IL-17F gene 7488 T > C polymorphic site than the individuals with a T allele. It was shown that ATT and GCT haplotype carriers had a greater disease risk compared with the GTT haplotype carriers.ConclusionsIn conclusion, IL-17F gene 7488 T > C polymorphism was found to be associated with asthma in the Turkish population. The IL-17 gene should be further investigated as a potential candidate gene in predicting asthma susceptibility and in the treatment of asthma.© 2022. Royal Academy of Medicine in Ireland.

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