• Pak J Med Sci · Jan 2022

    Effect of Remdesivir on mortality and length of stay in hospitalized COVID-19 patients: A single center study.

    • Quratulain Shaikh, Samreen Sarfaraz, Anum Rahim, Mujahid Hussain, Rabeea Shah, and Sara Soomro.
    • Dr. Quratulain Shaikh, FCPS, MSc, Department of Internal Medicine, The Indus Hospital and Health Network, Karachi, Pakistan.
    • Pak J Med Sci. 2022 Jan 1; 38 (2): 405-410.

    ObjectivesTo see the difference in mortality among hospitalized COVID-19 patients given Remdesivir (RDV) with those who were not given RDV.MethodsA prospective cohort study was conducted on patients who were admitted to the COVID-19 isolation unit at The Indus Hospital, Korangi Campus Karachi between March and June 2020.ResultsGroups were similar in age and gender distribution. RDV group was more hypoxic, had severe ARDS and needed higher Oxygen support compared to non-RDV group (p=0.000). Median SOFA score was 2 in RDV vs 5 in non-RDV (p=0.000). More than moderate COVID pneumonia was found in 92% of the RDV group while 89% of non-RDV group (p value=0.001). Median day of illness to administer Remdesivir was 10. There was no difference in mortality (45.5% in RDV vs 40.4% in non-RDV; p=0.4) between the two groups. Median length of hospital stay was 12 days (IQR=7.5-14.5) in RDV group compared to 10 days (IQR=6-14) in non-RDV group (p=0.009).ConclusionRDV did not show any difference in in-hospital mortality in our patients. More patients had severe ARDS in the RDV group while patients in the non-RDV group had higher SOFA score and multi-organ failure. Length of stay was longer in patients receiving Remdesivir.Copyright: © Pakistan Journal of Medical Sciences.

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