• Neuroscience · Aug 2022

    Review

    Unraveling molecular and system processes for fear memory.

    • Tadeu Mello E Souza.
    • Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde (ICBS), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil; Programa de Pós-Graduação em Neurociências, ICBS, UFRGS, Porto Alegre, Brazil. Electronic address: msouza@ufrgs.br.
    • Neuroscience. 2022 Aug 10; 497: 14-29.

    AbstractFor decades, Izquierdo and colleagues contributed to building the notion that declarative memory requires different processes at the molecular and systems levels. This review aims to discuss part of Izquierdo's legacy, mainly but not exclusively that related to fear memory. First, some of the philosophical and evolutionary issues that arise from declarative memory definition are presented. Then, the underlying processes of declarative memory are depicted, discussing the formation, the nature and the progression of the memory trace in short-term and long-term memory, and describing the involvement of some molecular cascades in the hippocampal formation, mesocortex and frontal areas. Potential contributions to therapy or understanding cognitive processes are mentioned.Copyright © 2022 IBRO. Published by Elsevier Ltd. All rights reserved.

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