• Karin Obreque, Rosemarie Mellado, and Max Andresen.
• Escuela de Química y Farmacia, Facultad de Química y Farmacia, Pontificia Universidad Católica de Chile, Santiago, Chile.
• Rev Med Chil. 2021 Sep 1; 149 (9): 1258-1266.

BackgroundPatients hospitalized in intensive care units (ICU) are at higher risk of having adverse drug reactions (ADR).AimTo determine risk factors for ADR, through intensive pharmacological surveillance at the ICU.Patients And MethodsAn observational, descriptive and prospective study was made, determining risk parameters in patients who experienced ADR.ResultsEighty-five patients were surveilled and 24 (28%) had an ADR. A total of 48 drugs responsible for at least one ADR were identified. Seventy-three percent ADR were moderate and 27% were severe. The clinical variables significantly associated with ADR were a history of allergies, a high body mass index, the reason for admission, an APACHE II score ≥ 14 points, the use of invasive mechanical ventilation and more than seven days of hospitalization. The pharmacological variables associated with ADR were polypharmacy and medication associations and combinations.ConclusionsThe identified risk factors have a great impact on pharmacokinetic and pharmacodynamic parameters, and should be considered to avoid the appearance of ADR.

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