• ZulfaniaDr. Zulfania, M.Phil. Department of Physiology, Rehman Medical College, Peshawar, Pakistan., Adnan Khan, Sohaib Rehman, and Tahir Ghaffar.
• Dr. Zulfania, M.Phil. Department of Physiology, Rehman Medical College, Peshawar, Pakistan.
• Pak J Med Sci. 2018 Nov 1; 34 (6): 1483-1487.

ObjectiveTo determine the Homocysteine levels in type 2 diabetics and correlate homocysteine with HbA1c levels, BMI, blood pressure and duration of diabetes.MethodsThis cross-sectional study was conducted in Endocrinology Unit of Hayatabad Medical Complex (HMC) Peshawar and Rehman Medical Institute (RMI) Peshawar over a period of six months from July 2015 to December 2015. Data was recorded and analyzed in SPSS v 20. P value of less than 0.05 was taken as significant. Bivariate Pearson's correlation test was used to see the relationship between homocysteine and BMI, systolic BP and duration of diabetes.ResultsOne hundred twenty five patients were included in our study in which female were 68% and 32% were male with mean age of 51.45 ±8.37 years. Mean BMI expressed in kg/m2 was 28.71±4.76, mean systolic blood pressure was 130±20.98 mmHg, mean diastolic blood pressure was 83.36±11.28 mmHg and mean duration of diabetes was 7.018± 6.18 years. Significant correlation was found between systolic blood pressure (r: 0.239, p: 0.007) and duration of diabetes with homocysteine (r: 0.302, p: 0.001). The correlation of homocysteine with HbA1c and BMI was not significant.ConclusionSystolic blood pressure and duration of diabetes showed a significant positive correlation with homocysteine. The correlation of homocysteine with HbA1c was not certain from researcher's point of view and further studies of larger sample size and longer duration must be conducted to ascertain the association between the two variables.

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