• Yan Cao, Xinjing Wang, Zhihong Cao, Chunyan Wu, Dongmei Wu, and Xiaoxing Cheng.
• Key Laboratory of Tuberculosis Prevention and Treatment, and Beijing Key Laboratory of New Techniques of Tuberculosis Diagnosis and Treatment, Institute of Tuberculosis, the 309 Hospital, Beijing, China.
• Arch Med Sci. 2018 Oct 1; 14 (6): 121212321212-1232.

IntroductionThe association of mannose-binding lectin gene (MBL2) polymorphisms with tuberculosis susceptibility was inconclusive. In this study, a meta-analysis of 22 case-control studies was carried out to assess the effect of MBL2 polymorphisms on tuberculosis risk.Material And MethodsA search was performed in Embase, PubMed and Web of Science up to Sep 30, 2015. Odds ratio (OR) and 95% confidence interval (95% CI) were used to assess the association. Statistical analyses were performed using STATA 12.0 software.Resultsrs1800451 was associated with a decreased tuberculosis risk in the allele model (C vs. A: OR = 0.93, 95% CI: 0.86-1.00, p = 0.050). In analyses stratified by ethnicity, rs7096206 (C/G: OR = 1.31, 95% CI: 1.10-1.57, p = 0.003; GG vs. GC + CC: OR = 0.69, 95% CI: 0.56-0.85, p < 0.001) and A/O (O/A: OR = 1.34, 95% CI: 1.10-1.64, p = 0.004) were associated with tuberculosis risk in Asians, A/O (AA vs. AO + OO: OR = 0.71, 95% CI: 0.51-0.99, p = 0.041) and rs1800451 (AC vs. AA + CC: OR = 2.70, 95% CI: 1.27-5.74, p = 0.010) were associated with tuberculosis risk in Americans, and rs1800451 (C/A: OR = 0.92, 95% CI: 0.86-0.99, p = 0.035) was associated with tuberculosis risk in Africans. Additionally, rs1800450 (B/A: OR = 0.42, 95% CI: 0.25-0.72, p = 0.001) was associated with tuberculosis risk in Europeans.ConclusionsThe MBL2 rs1800451 polymorphism is associated with decreased TB risk in the general population, and A/O, rs7096206, rs1800450 and rs1800451 are likely to be associated with the risk for some specific ethnic groups.

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