• Tohoku J. Exp. Med. · Apr 2022

    Severe Acute Respiratory Syndrome Coronavirus 2 Induces Hepatocyte Cell Death, Active Autophagosome Formation and Caspase 3 Up-Regulation in Postmortem Cases: Stereological and Molecular Study.

    • Shirazi TehraniAtefehALaser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences.Hearing Disorders Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences., Tabatabaei MirakabadFatemeh SadatFSHearing Disorders Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences., Mohammad-Amin Abdollahifar, Shamim Mollazadehghomi, Shahram Darabi, Mehdi Forozesh, Mostafa Rezaei-Tavirani, Gholam-Reza Mahmoudiasl, Behnaz Ahrabi, Zahra Azimzadeh, and Allah AbbaszadehHojjatHLaser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences.Hearing Disorders Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences.Department of Biology an.
    • Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences.
    • Tohoku J. Exp. Med. 2022 Apr 29; 256 (4): 309-319.

    AbstractThis research investigated the histopathological changes in the tissue of the lung, heart and liver, hepatocyte cell death, autophagy, and the apoptosis inductions in the postmortem cases. Since December 2019, coronavirus disease 2019 (COVID-19) has become a significant global health concern. In order to clarify the changes in tissues of the lung, heart and liver by COVID-19, samples were taken from five patients who died of COVID-19 and five control cases, and the pathological changes in the lung, liver, and heart tissue were studied by X-ray, computed tomography, histological studies, and stereological analysis. The formation of hyaline membranes, alveolar wall edema, and fibrin exudate was seen on histological analysis of the lungs in the COVID-19 group. Stereological analysis illustrated the number of hepatocytes, volume of the sinusoid, and volume of the liver have been decreased, however the pathological changes in the heart tissue were not observed. Serum levels of alanine aminotransferase, aspartate aminotransferase, blood urea nitrogen, and angiotensin-converting enzyme significantly increased. Real-time PCR results showed that the Bcl2, Caspase3, ATG5, and LC3 decreased while the Bax increased. COVID-19 causes fibrotic changes in the lung tissue and hepatocyte mortality in the liver tissue. Besides, it elevates the level of apoptosis and autophagy markers.

      Pubmed     Free full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…

Want more great medical articles?

Keep up to date with a free trial of metajournal, personalized for your practice.
1,694,794 articles already indexed!

We guarantee your privacy. Your email address will not be shared.